Showing posts with label zoonotic. Show all posts
Showing posts with label zoonotic. Show all posts

Thursday, April 30, 2009

Will Swine Flu Be an Economic Tipping Point?



Pandemics have been with us for a long time, are ongoing, and have never gone away.

Anyone heard of malaria, HIV, cholera, or tuberculosis?

All are huge killers, with millions dying every year across the globe, and no one blinks.

Regular-old influenza is a seasonal pandemic we have already normalized.

Consider this: in the average year, 30,000 to 50,000 people die in the U.S. from the flu, and across the globe the death toll is about 20 to 30 times that.

Ho hum. Let us bury the dead, stay calm and carry on.

So what's new about the swine flu pandemic that has everyone aflutter?

Well for one thing, the speed of transmission is pretty darn impressive.

A hat tip to the airlines and mass transit which have helped make that possible.

Another issue is that this stuff may be pretty virulent. We don't have a good denominator to work with yet, so we're not sure, but there's some small sign this strain of flu might be a bit stronger than the stuff we normally see. That, combined with the speed of transmission, gives epidemiologists a reason to worry.

The good news is that we are not living in the world of 1918.

We have better communications, better monitoring abilities, and more health care interventions than we did back then.

The bad news is that today's flu is being spread much faster, and our vaccine-producing technologies are still very old-fashioned, very slow, and very labor-intensive.

The bottom line here is that there is no way to make enough vaccine to stop a pandemic once it begins to really roar down the track.

We will just have to ride it out.

Another bit of bad news is that our crowded world has become a particularly flu-friendly place, and we are likely to see more of this kind of thing in the future.

As a 2005 article entitled "Preparing for the Next Pandemic, put it:


It is sobering to realize that in 1968, when the most recent influenza pandemic occurred, the virus emerged in a China that had a human population of 790 million, a pig population of 5.2 million, and a poultry population of 12.3 million; today, these populations number 1.3 billion, 508 million, and 13 billion, respectively. Similar changes have occurred in the human and animal populations of other Asian countries, creating an incredible mixing vessel for viruses.

Another bad sign
is that the current flu epidemic appears to be striking a disproportionately high number of healthy people between the ages of 18 and 40 years, which suggests a virus-induced "cytokine storm" may be occurring inside today's swine flu victims.

In a cytokine storm, the human immune system is pushed over the edge, and an auto-immune "do-loop" leads to acute respiratory distress syndrome, and that can lead to the kind of death knell numbers we saw back in 1918. As Michael Osterholm noted back in 2005:

If we translate the rate of death associated with the 1918 influenza virus to that in the current population, there could be 1.7 million deaths in the United States and 180 million to 360 million deaths globally.

So should we all be freaking out?

  • No.


  • Yes.

Paradoxically, both answers can be true at the same time.


The chance of any one individual actually dying from swine flu, even under a worst-case scenario, is not very high.

That's the good news.

Relax.

The bad news is that a real pandemic could lead to schools and offices shutting down, restrictions on airplane travel, and a shuttering of subway and train lines.

Add to that economic catastrophe, a further drop in productivity due to people getting sick, and well people being forced to stop work in order to take care of family members who are sick, and the undertow of an economic vortex could be set in motion.

Panic!


What if the next pandemic were to start tonight? If it were determined that several cities in Vietnam had major outbreaks of H5N1 infection associated with high mortality, there would be a scramble to stop the virus from entering other countries by greatly reducing or even prohibiting foreign travel and trade. The global economy would come to a halt, and since we could not expect appropriate vaccines to be available for many months and we have very limited stockpiles of antiviral drugs, we would be facing a 1918-like scenario.

.... we could vaccinate fewer than 500 million people — approximately 14 percent of the world's population. And owing to our global "just-in-time delivery" economy, we would have no surge capacity for health care, food supplies, and many other products and services. For example, in the United States today, we have only 105,000 mechanical ventilators, 75,000 to 80,000 of which are in use at any given time for everyday medical care; during a garden-variety influenza season, more than 100,000 are required. In a pandemic, most patients with influenza who needed ventilation would not have access to it.

We have no detailed plans for staffing the temporary hospitals that would have to be set up in high-school gymnasiums and community centers — and that might need to remain in operation for one or two years. Health care workers would become ill and die at rates similar to, or even higher than, those in the general public. Judging by our experience with the severe acute respiratory syndrome (SARS), some health care workers would not show up for duty. How would communities train and use volunteers? If the pandemic wave were spreading slowly enough, could immune survivors of an early wave, particularly health care workers, become the primary response corps?

Health care delivery systems and managed-care organizations have done little planning for such a scenario

Bottom line: An already weakened global economy could be pushed into a very serious free fall.

... Or not.

After all, as I noted at the beginning of this post, the world is being assailed by "pandemics" all the time, and yet we, as a species, continue to roll forward without too much of a hitch in our giddy up.

Death? That old thing?

Who cares about AIDS, or cholera, or malaria?

Let's talk about something interesting, like Mel Gibson's divorce.

Of course, that will change quickly if over-educated white people start dying by the train full. Then it really will be time to panic!

That said, I seriously doubt that swine flue will be the Last Waltz.

Let us remind ourselves, however, that unless we change the way we do business, there will be a Last Waltz some day, and disease will be part of that.

As Issac Asimov noted in a speech entitled "The Future of Humanity,"


"There is no need to decide whether to stop the population increase or not.

There is no need to decide whether the population will be lowered or not.

It will, it will!

The only thing mankind has to decide is whether to let it be done in the old inhumane method that nature has always used, or to invent a new humane method of our own [i.e. family planning and birth control].

That is the only choice that faces us; whether to lower the population catastrophically by a raised death rate, or to lower it humanely by a lowered birth rate.

And we all make the choice."

Right.

Or as I like to put it: "If we continue to breed like rats, then one day we are sure to die like flies."

In the interim, however, please pass the bacon.

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Friday, April 24, 2009

Swine Flu and the Next Pandemic



Back in 2005, I noted that the next major global pandemic was likely to come out of China or Southeast Asia due to the fact that the Chinese routinely mix the excrement of humans, pigs, fish and fowl and then dose it with massive amounts of antibiotics in order to keep fish healthy in over-crowded fresh-water aquaculture ponds

Now comes word that 5 new swine flu cases have appeared in California and Texas, and that "the unusual strain of the respiratory infection is spreading from person to person."

Right.

The Center for Disease Control says "We don't think this is time for major concern around the country."

They are probably correct.

That said, this is how it will start, mark my words.

  • Follow Up:
    It looks like things are heating up, Voice of America reports: "Mexican and U.S. officials are taking emergency steps to contain the possible outbreak of a new multi-strain of swine flu that has killed at least 20 people and may be responsible for scores of other deaths.Mexican health officials confirmed at least 20 deaths associated with the new flu strain Friday and ordered the most sweeping shutdown of public gathering places in decades. Authorities closed schools, museums, libraries and theaters in the capital, Mexico City, to try to contain any possible outbreak. Many people in the capital were wearing face masks while in public. Authorities say 1,000 people have become ill."

    Without being too alarmist, this thing is spreading way too fast and it is not too benign and it is not even normal flu season. Not good. Even more not good is that New York health officials began testing 75 students at a Queens school on Friday, suspecting flu.

    "The new virus has genes from North American swine influenza, avian influenza, human influenza and a form of swine influenza normally found in Asia and Europe, said Nancy Cox, chief of the CDC's Influenza Division."

  • Related Posts
    ** Populations, Oceans and Influenza
    ** Sharing Death and Disease Across Species
    ** China, Export Fish, Antibiotics & the Next Plague

Friday, June 29, 2007

China, Export Fish, Antibiotics & the Next Plague



The FDA is blocking imports of Chinese farm-raised seafood after finding 25% had residues of illegal antibiotics and chemicals. (FDA Statement)

I am glad to see the FDA taking this step as it is a good first step toward reducing the threat of a global pandemic caused by putting huge quantities of antibiotics into farm-raised fish. For more on that (and why it is a more serious problem in China that elsewhere), see >> Populations, Oceans and Influenza and Sharing Death and Disease Across Species

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